Rj.
The 200 acres of this plant in NY, could mean the ground was too wet making it more restrictive for the use of the majority of herbicides, following the label.
An area this large committed to one plant generally will not last in the long run. This is essentially monoculture and monoculture is an uphill battle in natural systems. Something has to give, irrespective of further human intervention. This area is a resource to be harvested largely by other organisms at some point.
Even if the 200 acres in NY, is a summation rather than a grand expanse, the microbial solution is scalable.
Invasive species need to be addressed individually and from their total biology. More information is needed in characterizing these areas of monoculture from the ground up. The soils microbial foundation is the placenta feeding these rare colonies and the invasive plants in these numbers is more a symptom. The management has to be on the microbial level. It is possible to change soil microbial metabolic preferences that would not support the current monoculture. You have to make an offer they can't refuse metabolically if applied the symptom will weaken and fade away.