I grow both, but the decision isn't made whether it is Heirloom or Hybrid. When I'm shopping for seeds, the 1st thing I look at is the description of great taste. Then I choose the fruit size/type: Cherry, Paste, Slicing. From there I check out different colours and finally the choose between a vine(indeterminate) or bush(determinate). I don't base my choice on whether it is Heirloom or Hybrid.
There are a lot of great tasting Hybrids that have greater disease resistance and have prolific fruit production which I would choose over a Heirloom that is prone to cracking, bottom end rot or blight. It is very disappointing to have visibly healthy plant but with all the fruit affected with bottom end rot
If colour is the focus, the Heirlooms win. Chocolate Cherry, Yellow Pear, Purple Cherokee and Green Zebra are quite different and there are no Hybrids to sub for them.